Snoop's debut solo album, Doggystyle, produced by Dr. Dre, was released by Death Row Records in November 1993, and debuted at number one on the popular albums chart, the Billboard 200, and on Billboard's Top R&B/Hip-Hop Albums chart. Selling 800,000 copies in its first week, Doggystyle was certified quadruple-platinum in 1994 and bore several hit singles, including "What's My Name?" and "Gin & Juice". In 1994, Death Row Records released a soundtrack, by Snoop, for the short film Murder Was the Case, starring Snoop. In 1996, his second album, Tha Doggfather, also debuted at number one on both charts, with "Snoop's Upside Ya Head" as the lead single. The next year, the album was certified double-platinum.

After leaving Death Row Records in January 1998, Snoop signed with No Limit Records, releasing three Snoop albums: Da Game is to Be Sold, Not to Be Told (1998), No Limit Top Dogg (1999), and Tha Last Meal (2000). In 2002, he signed with Priority/Capitol/EMI Records, releasing Paid tha Cost to Be da Boss. In 2004, he signed to Geffen Records, releasing his next three albums: R&G (Rhythm & Gangsta): The Masterpiece, then Tha Blue Carpet Treatment, and Ego Trippin'. Priority Records released his album Malice 'n Wonderland during 2009, followed by Doggumentary during 2011. Snoop Dogg has starred in motion pictures and hosted several television shows, including Doggy Fizzle Televizzle, Snoop Dogg's Father Hood, and Dogg After Dark. He also coaches a youth football league and high-school football team. In September 2009, EMI hired him as the chairman of a reactivated Priority Records.

In 2012, after a trip to Jamaica, Snoop announced a conversion to Rastafarianism and a new alias, Snoop Lion. As Snoop Lion he released a reggae album, Reincarnated, and a documentary film of the same name, about his Jamaican experience, in early 2013. His 13th studio album, Bush, was released in May 2015 and marked a return of the Snoop Dogg name. His 14th solo studio album, Coolaid, was released in July 2016. Snoop has 17 Grammy nominations without a win. In March 2016, the night before WrestleMania 32 in Arlington, Texas, he was inducted into the celebrity wing of the WWE Hall of Fame, having made several appearances for the company, including as master of ceremonies during a match at WrestleMania XXIV. In 2018, Snoop announced that he was "a born-again Christian" and released his first gospel album, Bible of Love. On November 19, 2018, Snoop Dogg was given a star on the Hollywood Walk of Fame. He released his seventeenth solo album, I Wanna Thank Me in 2019.