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The first animated series by Universal Studios, the show was heavily influenced by Japanese anime.

Set in the years 2119-2121, decades after humanity ("Terrans") has expanded beyond Earth, terraforming and colonizing Mars and Venus. In the backstory, "Neosapiens", an artificial humanoid race created as worker/slaves for the Terrans. There is also an independent faction of Terrans known as the Pirate Clans that have raided space freighters.

Earth Congress dispatches the entire Exofleet, humanity's space force to counter the pirate threat. While away, the Neosapiens put into plan a new insurrection. The series then follows the exploits of Able Squad, an elite unit of exoframe pilots. Their exploits unfold against the backdrop of the ongoing Neosapien War, as the squad participates in events often crucial to turning its tide. The show features a realistic outlook on war:

Many characters die in combat, military operations are carefully planned and scouted in advance, and psychological effects of warfare are examined.