The series follows the life of anti-social, pain killer addict, witty and arrogant medical doctor Gregory House (Hugh Laurie) with only half a muscle in his right leg. He and his team of medical doctors try to cure complex and rare diseases from very ill ordinary people in the United States of America. Using a crack team of doctors and his wits, an antisocial maverick doctor specializing in diagnostic medicine does whatever it takes to solve puzzling cases that come his way.

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