Gomphocarpus physocarpus is widely used in traditional medicine in South Africa. The roots are used to treat stomach ache. Leaves are dried and ground into a powder that is taken as snuff for headaches. The milky latex is used to treat warts. Seeds are blown away from the pods as a charm to placate the ancestors. The stems are used for fibre. Fresh stems and leaves stuffed into mole holes are said to be an effective deterrent. This plant is poisonous if ingested and has caused death to sheep fed large amounts.

Seeds are viable and suitaible for planting. 


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