Botanist's Cystiren is a combined food supplement that contains standardized extracts of American cranberry (patented CystiCran complex) and Goldenrod, which together have a positive effect on the function of the urinary tract and urinary system. Cystirene is a good remedy for cystitis, urethritis, pyelonephritis. It has a diuretic, immunomodulatory and anti-inflammatory effect. Action: Cranberry (Vaccinium macrocarpon) - it has a valuable effect - the anti-adhesive effect on the bacterium E.coli (the main cause of cystitis). In the last few years, it has been conclusively proven that this effect is due to a specific type of proanthocyanidins called type C, found only in it so far. This is the reason why in 2004 it was protected by AFSSA as the only fruit reduces the attachment of E. coli to the walls of the urinary tract. The virulence of a number of pathogenic E. coli strains is due to the adhesins expressed by them, the so-called P-Fimbriae, through which they attach to specific receptors on uroepithelial cells, because the immune system does not recognize E. coli as pathogenic. In contrast, proanthocyanidin type A recognizes E.coli unmistakably, preventing it from binding to receptors on the surface of the urinary tract. By inhibiting this connection, the bacteria fail to attach and are "transported" through the urine outside the body. Unlike the antibiotic, which acts at the macro level (not so selectively), proanthocyanidins type A act much more precisely. They destroy only the binding of the pathogenic bacterium to the receptors, without destroying the entire population of E. coli, some strains of which are part of the beneficial intestinal microflora. In addition, antibiotics and chemotherapeutics can kill other beneficial bacteria as well as induce the development of resistant L-forms. Goldenrod, Solidago Virgaurea (5% flavonoids) - is a European herb, known and used since ancient times. It is known that it is rich in various flavonoids and anthocyanidins, the synergism of which is due to its healing effect. It has diuretic, analgesic and anti-inflammatory effects. The efficacy of Goldenrod extract has been proven in a clinical study. 745 female patients, between 12 and 94 years of age with pronounced dysuria, were studied. A 14-day treatment with Goldenrod extract, 380 mg, 3 times / day was performed. In 69.2% of cases, a significant reduction in pain was observed, as well as relief of other symptoms of cystitis. In addition, false urges to urinate have also reduced their frequency. Antispasmodic effect - the flavonoids in the Goldenrod can affect the relaxation of smooth muscles. It can be said that this effect is due to the inhibition of protein kinase C. It acts as a competitive antagonist of acetylcholine in muscarinic receptors, which leads to relaxation of the smooth muscles of the bladder. Antibacterial effect - The antibacterial activity of Goldenrod has been tested in vitro against urogenital bacterial pathogens (Staphylococcus aureus, Staphylococcus epidermidis). The result shows strong antibacterial activity not only against these bacteria, but also against Bacillus subtilis, Bacillus pumilis, Proteus mirabilis, Micrococcus luteus. The active ingredients in Goldenrod have been found to cause inhibition of dihydrofolate reductase activity. Antifungal effect - A series of studies have shown that isolated triterpenoid saponins of Goldenrod have a pronounced activity against some Candida species (Candida albicans, Candida tropicalis, Candida krusei, Candida parapsilosis, Candida pseudotropicalis, Candida guilliercromonta, Cryndidoformin). Immunostimulatory effect - Immunomodulatory effect is found in the action of triterpene saponins and flavonoids in the Goldenrod. They have been shown to induce macrophages and activate NK cells.
Composition Standardized Cranberry Extract (CystiCran 40% PACs) 45 mg The standard daily dose of CISTIREN contains 72 mg of PACs Standardized extract of Goldenrod (5% flavonoids) 180 mg
How to use:
<In acute conditions: Two tablets of Cistiren twice a day (minimum 7 days).
<For chronic conditions: Twice one tablet (minimum 3 months). Method of administration: With a large glass of water, on an empty stomach. It can be taken by children over 7 years, pregnant and lactating.
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