The ASUS PRIME B250M-PLUS uses the Intel LGA 1151 CPU socket. Any compatible Intel CPU will have the same socket entry. It uses the DDR4 memory type, with maximum speeds of up to 2400 MHz, and 0 DDR4 slots allowing for a maximum total of 64 GB RAM.

The Micro-ATX ASUS PRIME B250M-PLUS should fit into all ATX cases, but its smaller size allows you to downsize your system build as a whole. Its size comes at the cost of features, so there are likely to be far fewer connections and expansion options available than in a larger motherboard. 

The ASUS PRIME B250M-PLUS does not support onboard graphics. Any system build that uses this motherboard therefore requires a separate graphics card, or a processor that has a GPU on the same die, such as AMD APU processors. There are 2 PCIe x16 slots on this motherboard. This means it is perfectly capable of accommodating the latest graphics cards, although it is important to try and use a graphics card with the same graphics card interface of PCIe v3.0, as anything below will not reach the motherboard's potential, and anything above will have its performance slashed to the bandwidth maximum of the ASUS PRIME B250M-PLUS's PCIe v3.0. The ASUS PRIME B250M-PLUS supports up to 2 AMD Crossfire connected graphics cards for improved overall graphical performance at the cost of multiplied graphics-based power consumption as well as the price of the cards themselves. Nvidia SLI is not supported.

The ASUS PRIME B250M-PLUS has 2 USB 2.0 slots and 3 USB 3.0 slots. USB 3.0 slots are theoretically capable of data transfer speeds of up to 5 Gbit/s, which is over 10 times faster than the USB 2.0 top speed of 480 Mbit/s. Although USB 2.0 slots alone currently serve as well as ever, an upgrade would better future-proof your system as more USB 3.0 compatible peripherals emerge. USB 3.0 is also backwards compatible with USB 2.0, which means you do not even have to use the newer slot functionality if you do not wish to.